Mike Myers pretty much just took a break from acting and writing for awhile, only doing the occasional guest spot here and there. Lucy Liu has had a steady TV gig on CBS and does a lot of non-acting art. Emile Hirsch has been steadily acting the whole time, just not as many "big" movies. He also took over the VA role on Trollhunters after Anton Yelchin passed away. Alicia Silverstone switched over to behind the camera roles, production mostly iirc. John Leguizamo's had steady work for years, a lot of it VA work (Ice Age series) but generally just takes jobs he likes regardless of the size of the project. Etc.. etc..
Most actors careers don't "die" unless they were legitimately flash-in-the-pan stars. Very rarely does anyone reach top billing status and stay there for decades. Either they take a break or they stop doing blockbusters. I can't think of any actor under 50 whose been able to do it and the older ones (Tom Cruise, Clint Eastwood, Tommy Lee Jones) are either holdovers from the older way Hollywood worked, they produce and finance their own vehicles, or both.
