If indeed it takes place after DMC4, then at this point DMC2 is pretty much non-canon.
I mean I can't blame Capcom for wanting people just to forget that game existed. Cause boy.... but on the other hand if I remember right the closing shot was Dante riding his motorcycle into hell which for as fucking boring of a game as DMC 2 was is a real fucking cool premise that Dante is just riding straight into hell to fuck shit up.