What are the major differences between Warren and Sanders?
They both seem similar but Warren messed up with the whole Native American thing and sounding like Tim Cook.
Biggest is her coalition is built around people very interested in politics, while Bernie's coalition is built around people not very interested in politics. People already interested in politics is definitionally a red ocean and makes it a lot less likely for any change to occur beyond the usual back and forth hot potato of party control of the white house. She also has support of some insiders that has Bernie supporters feel suspicious, but I would note that she was far more aggressive against Obama's worst appointees when he was president than Bernie was.
There's also worries about what she'd do with the military compared to Bernie because she's a lot more timid when it comes to speaking about foreign policy. When you compare issue by issue on concrete policy statements, technically they're the same, but it feels telling when a firebrand like Warren stops being a firebrand about something.
And finally, it seems extremely unlikely that she'd make a big fight about healthcare as a defining issue when she's in office. And given how unlikely it is for Bernie to get anything at all from congress, it might be a good thing to not waste your limited time in office on a issue that's not going to happen any time soon, but Bernie supporters would say it's too important of an issue to give up on prematurely.
Otherwise, I'm pretty sure both would follow through on the list of highly impactful executive orders that Obama didn't do but legally probably could have, which is the main reason why I think Bernie vs Warren is unimportant but Bernie and Warren vs everyone else is important, because I'm pretty sure no one else would go above what Obama did.