I'll always recommendThe Quest for El Dorado. A card drafting & racing game. Very easy to learn. Very simple. Variable set up as well. Actually perfect at 2 players or 4 players.
The Quacks of Quedlinburg is another great game but pricier. I think the expansion just came out too.
Nice, i'll check those out. My niece of 6 comes around often but all the games I have are for 10+ year olds.I asked here some time ago for recommendations for my nieces, and among several options the one which really resonated well with them was Incan Gold. Easy enough to understand, and still very enjoyable for adults playing along.
edit: ok my bad I should have specified age better.