I hope that one day Dragon Ball will consistently have villains on the level of Broly (Super), Cell and Frieza in terms of characterization. A route I'd like to see them explore would act as a point of reflection for Goku and build upon Whis and Vegeta's warning regarding his penchant for mercy and second chances. Create a villain that's the survivor of Frieza's tyranny throughout the universe following his restoration at the end of ToP/or Broly. They, along with other characters, journey throughout the stars hunting Frieza and his force...which brings them into conflict with Broly because Cheelai and Lemo are targets of theirs as well. However, their ultimate target is Goku for his role in reviving Frieza (regardless of the universal stakes) and the destruction of the Earth, so Goku can know the pain that they carry. The band traveling with the primary antagonist means the involvement of other (powerful) Z fighters.
Next, find some way to incorporate Cooler into canon and with him possessing more power than his younger sibling. He's investigating what happened to his brother following his disappearance on Earth. Re-write him to actually begrudgingly care for his little brother and is also seeking the dragon balls to revive King Cold and learn of Frieza's whereabouts/what happened to him.
Following that, I'd like to see them build upon the duality theme that's been ongoing in Super. A villain fashioned from the chaos of reality's birth, a foil to the Grand Priest and realty's order would be cool. They'd be a being imprisoned within the deepest levels of Hell and would be freed by sole ancient cult that worships them as a messiah. Maybe they could be the penultimate big bad in Super that ends the series.
Finally, I'd like to see the return of the original Super Saiyan/SS God. His/Her return is achieved by Goku receiving the universal dragon balls at the culmination of the last battle and wishing for their return so he can do battle with them. His wish is granted and regardless of Goku's power gains from sparring with Broly and his complete mastery of Ultra Instinct he is beaten by the character's base form. Though Goku loses, the OG is impressed with his efforts and refusal to admit defeat and offers to train Goku if he wishes it. Goku accepts the offer after mulling that Goten is now an adult and that ChiChi doesn't cook as often as she once did.
Moro seems like an ok villain so far and his design is a breath of fresh air but I want characters with some depth to them and have a reason for being.