nah, from Marvel Studios' end, disentangling Spidey from the MCU is quite easy: just don't mention him again.
Okay, that's a bit glib, we don't know exactly what their plans are/were for the character going forward, but absolutely nothing in FFH necessitated narrative follow-up anywhere outside the next Spider-Man solo film, and they just announced a dozen or so MCU projects that are unlikely to be impacted at all by the Spider-Man rights.
Now, from Sony's end, it would be a lot harder and I more or less agree. In theory, they're free to continue the current franchise on their own, but in practice, it would be a creative and logistical nightmare that would require a roomful of lawyers to first sit down and determine exactly what elements from Homecoming/FFH Sony is legally allowed to use on its own, and it's hard to imagine that ending well for anyone.