For large rotations I found the secret sauce. Get a gaming mouse, or any kind of programmable mouse with 3 or 4 buttons on the side. I use the Razer Naga Trinity.
Your main hotbar is just 1,2,3,.... Another hotbar is Ctrl+1, Ctrl+2, ... Another is Alt+1, Alt+2, .... And still another one can Shift+1, Shift+2, etc.
then bind the thumb-buttons on the mouse to Ctrl, Alt, and Shift. All you have to do now is press one of the thumb buttons with the corresponding number and you have easy access to 40+ actions without taking hands off the mouse.
Your main hotbar is just 1,2,3,.... Another hotbar is Ctrl+1, Ctrl+2, ... Another is Alt+1, Alt+2, .... And still another one can Shift+1, Shift+2, etc.
then bind the thumb-buttons on the mouse to Ctrl, Alt, and Shift. All you have to do now is press one of the thumb buttons with the corresponding number and you have easy access to 40+ actions without taking hands off the mouse.