Guy cures himself of lactose intolerance via home made virus biotech

thediamondage

Member
Oct 25, 2017
6,940
So this guy has been lactose intolerant all his life. He's had a dream of attending university and learning enough to cure his lactose intolerance.

He grows a virus at home using off the shelf biotech tools, presumably bought or borrowed, grows a virus culture, makes some pills, and swallows the pills.


Longer version: he lacks the protein in his small intestines to break down lactose. He can easily find the DNA for the right protein to digest lactose, but how do you make it grow inside your small intestine? He grows a bacteria with the right DNA, then tests which cells in his body would withstand the process of accomodating the new DNA, grows those cells in a culture to mass produce it (which is a virus), turns the virus into a solid and puts into a gel cap and swallows it.

Literally this dude has created a new organism and its solved one of his lifetime problems but this seems like some scary ass shit someone could do in their basement. I don't think CRISPR was involved here at all, but thats a step up in creating bespoke viruses and bioweapons. And it seems relatively easy...
 

Skittles

Member
Oct 25, 2017
6,472
Really awesome that he did this, hope there's no side effects.

On the otherhand, coulda started the zombie apocalypse
 

IDreamOfHime

Member
Oct 27, 2017
8,972
Isn't this nobel prize winning material?
Like didn't the dude who discovered the cure/cause for stomach ulcers test it on himself too?
 

Stiltzkin

The Fallen
Oct 25, 2017
6,176
I need this dude to make some for me now. I love milk and I can't drink more than a glass without running to the bathroom...
 

WedgeX

Member
Oct 27, 2017
8,338
I’ll watch the video eventually, just not at work, but I’ve got some questions.

What is the output of the virus breaking down the lactose? In the body of people - like me - with lactose intolerance, bacteria breakdown the lactose and output chemicals...leading to all the symptoms. With lactose free milk or using lactaid pills, there are no side effects.

If the outputs are minimal, get this thing FDA approval! I’d easy pay all the money for a cure.
 

ArgyleReptile

Member
Oct 25, 2017
4,129
Not able to watch, but how long has he been taking his pills? Feels like this is something we should wait a bit to see if there are any long term affects, no?
 

Violence Jack

Member
Oct 25, 2017
20,813
I too have been waiting all of my life to cure my lactose intolerance. But this seems a little flaky. Will wait for any side effects and hoping this dude didn't just create the T-virus.
 

Sybil

Avenger
Oct 27, 2017
1,324
impressive... though this sounds like this could go terribly, terribly wrong so you know lactase pills it is
 

tsmoreau

Member
Oct 27, 2017
606
I think this is more gut-bacteria breeding than gene therapy. I haven't watched the video but the OP description loses me when jumping from mass growing dude's own cells in a petri dish to those cells somehow being a virus which integrates the bacterial DNA into the dudes? Yeahbuwha?

Again, haven't watched, but it reads more to me like ingesting the bacteria to break down certain proteins that his body won't on their own. Custom gut bacteria is cool, still nutso and dangerous though.
 

Angie

Best Avatar Thread Ever!
Member
Nov 20, 2017
15,902
Kingdom of Corona
Holy S. All chances would say that attempting something like this at home, could go really bad really fast.
I'm glad nothing bad happened, and if this works I hope he shares the knowledge for a cure be available to those who suffer the same.
 

iksenpets

Member
Oct 26, 2017
5,095
Dallas, TX
By 2030, the leading cause of death among young men will be tech-bro self-experimentation, quickly eclipsing old concerns like narcotics, accidents, and murders.
 

SRG01

Member
Oct 25, 2017
5,939
I think this is more gut-bacteria breeding than gene therapy. I haven't watched the video but the OP description loses me when jumping from mass growing dude's own cells in a petri dish to those cells somehow being a virus which integrates the bacterial DNA into the dudes? Yeahbuwha?

Again, haven't watched, but it reads more to me like ingesting the bacteria to break down certain proteins that his body won't on their own. Custom gut bacteria is cool, still nutso and dangerous though.
It's gene therapy in the sense that he created a bacteriophage to infect intestinal bacteria, giving them the essential proteins to break down lactose.
 

Beartruck

Banned
Oct 25, 2017
4,939
Test it with real scientists and if it works, get fda approval and sell it. Then make a version for cats. My poor guy barfs his lungs out whenever he finds a crumb of shredded cheese on the floor, despite our best efforts.
 
Nov 22, 2017
75
This treatment will most definitely be transient and will not last (the nature of the virus he used and how he administered it to himself). Additionally, having treated himself with an AAV virus means he'll likely reject future AAV treatment (including ones developed by proper pharma companies).
 

Mendrox

Member
Oct 26, 2017
8,562
This gut bacteria breeding and nothing else which is already in use in medicine by giving somebody healthy shit with good bacteria to someone who lacks these bacteria. The people that did the procedure suddenly lost weight again, felt better etc.

"You are what you eat" is just true. And if the good bacteria are missing you will have problems. Gut is very important. Taking healthy shits is important.
 

tsmoreau

Member
Oct 27, 2017
606
It's gene therapy in the sense that he created a bacteriophage to infect intestinal bacteria, giving them the essential proteins to break down lactose.
Yeah, that was the part of the OP description that lost me. That's kinda important. What sort of virus base did he start with that both a) allows for safe infection of his native intestinal bacteria as well as b) changing of that gut bacteria's DNA in a predictable manner.

Again, haven't watched the video. But he did that above, that's pretty cool. Slightly different to what I was thinking and still dangerous as all hell get out, but I'm curious about the designed infection part.