I mean if you look at it both the theme and gameplay of Death Stranding seem to, from what we've seen so far, be very easy to summarise:
Theme: The importance of connections between people
Gameplay: Open-World Exploration & Traversal with Stealth/Action and Multiplayer elements
And that's fine. Themes and gameplay don't have to be incredibly convoluted for them to be good.
My concern is that, because he believes that he's making something "completely new," and that his game is deep enough to justify such a phrase that both the gameplay and theme will be bogged down by needless weirdness that, frankly, will add nothing to either the theme or the gameplay of the game. I keep making the comparison but it really reminds me of Twin Peaks: Season 3 where Lynch chose to twist a very simple story into something tedious and convoluted because there was no-one to wrangle in the 'wackiness'. Unless you're making something relatively short-form (and even then) I honestly think that throwing whatever you want out there without any regard for what it actually says is a bad way to make art.