Hopefully this list means that they are seriously thinking about these topics. With Nintendo it's often one steps forward and two steps back. Case in point, Peach in Mario Odyssey. But then again, they've given us Samus and Birdo.
My shoutout goes to the first Portal. I recently realized that its cast is almost all female, motherhood being its main themes (involuntary adoption to be more precise). You could criticize GladOs for the evil stepmother trope, be her lines are mostly super funny. She's like Lucille Bluth in Arrested Development. GladOs is allowed to be funny, despite her being insane. I happen to think that a sense of humor is what makes a character strong, it implies that they are in control. Traditionally male characters are often given a sense of humor but female characters are almost overly serious. Nathan Drake has a sense of humor, Lara Croft not so much, which I find telling.
What other funny female characters in video games can you think of? Am I overlooking something obvious?