Who knows, but I actually wouldn't be surprised if we get something of this sort. Times have changed, the likes of Bulletstorm and Doom have shown us how such can be done, and I definitely would like a new Prime to have a much more agile Samus.
Here are a few ideas I think would work:
-Samus gets a bit faster movement speed, FOV is on the wide side, right stick aiming+gyro.
-Power Beam has automatic fire (No more bashing the fire button until your finger bleeds) and fires with RZ, LZ engages the charged beam. These are your first two attacks in the game.
-There are three other beams you collect over time, to keep it simple these could be the same as in Prime 1. (Plasma, Ice, Wave Beam) The difference is, they are useful outside of puzzles and very specific enemies, and you can use them for strategy in combat. Instead of charging, each has an alt fire activated with LZ. (Eg. Plasma turns into a flamethrower, Ice throws an ice bomb, Wave lets you throw an EMP to jam the enemy's electronics and make them vulnerable)
-The L button activates missiles. These work pretty much like the micro-missiles in DOOM 2016.
-After turning morph-ball with A, you have all the normal controls, but you can use it in combat by dropping bombs on the enemies that damage them and feel satisfying to use.
-Pressing the right stick lets you use a melee attack. Perhaps a glory kill/risk-reward system like in Other M, Samus Returns, DOOM, etc.
-The Speed Booster makes a return, with a twist: you engage it by pressing the movement stick, you charge energy for a dash, the camera moves to third person and lets you aim where you are going to go, it takes two or three seconds to load and then you either confirm by pressing the fire button or cancel by letting go of the stick, you can use it to dash over specific surfaces for puzzles or... to ram into enemies.
-Since we ran out of shoulder buttons, the R button brings up a wheel where the upper half is for beam types and the bottom half is for visor types. Use the right stick to select.