I have a real soft spot for Mystical Ninja Starring Goemon on the N64 for its innate weirdness and tongue-in-cheek humor. My understanding is that Konami made a weird self-serious reboot around the PS2 launch and it bombed hard, basically dooming the franchise. It would be nice to see them try that series again, but with Konami being the way they are these days, it probably won't happen.