In a dream world:
Lets Go! Phanpy and Lets Go! Wooper
In reality:
Lets Go! Togepi and Lets Go! Marill
I think Lets Go 2 Johto would work at the very least. With the small additions to the overworld like the Pokemon tower Ghosts, the key hunt in Silph Co. e.t.c you could do a lot more in Johto. The ruins of Alph, Olivine Lighthouse, Ice Path, Lake of Rage, Whirl Islands, there is a fuck ton of interactivity like that waiting to be had. While its gonna sick waiting for such a game, Lets Go 2 Johto will be a slam dunk because its gonna be the dual region, feature rich game Lets Go should have been in the first place.