Yeah I think RE2 streets (and presumably RE3) are mostly made around what looks interesting, not even attempting to match it to the old map, so it gets a little weird when they decide to make use of the old map too. Can kind of make out where the playable areas are for this section by comparing the parts where it's edited and where it's not.
The skyline shot is digital I think, maybe the far distance isn't, but they have traffic moving along the road. This scene is set before the start of the game so it'll either be in the intro to the game, or found in video tapes/flashbacks if it's in there at all.
i'm guessing they've reworked the story so that Nemesis was assembled in the Umbrella Hospital / Laboratory you'll visit later in the game? Trailer makes it look that way.
