Sasuke is an emo edgelord character from the anime "Naruto". He's supposed to be popular, but a lot of people really hate him. His big brother killed their parents and their entire clan, and Sasuke vowed revenge. Sasuke randomly encounters the big brother one day and tries to kill him, but the big brother kicks Sasuke's ass with ease. He pins Sasuke to the wall (as seen in the meme pics) and says that he's too weak, that he doesn't have enough hate to win (because hate obviously makes you stronger). Big brother then finishes Sasuke off with a mind crush, causing him agonizing mental pain (to try to make Sasuke hate him more, because big bro was actually a secret hero, playing villian, and he wanted his little bro to score some popularity points with the good guys by killing him).
The meme is having other people kick Sasuke's ass, and then speechify in a way that fits this other person. The meme only really works if you know the other person, and can imagine them beating up Sasuke.