I got one of these a week ago and have been getting up to speed on where things are. I went with Autobleem because this shit is not my forte and there were a couple of guys on YouTube like Madlittlepixel who explained it pretty well and showed off features.
Now that I have Autobleem 0.5.1 on a stick with a bunch of games, I'm pretty into this thing. I realize that for some games the emulation may still be a bit off (haven't tried R4 via Autobleem but I know on the stock system it has issues and they included it in the 20 games anyway) but I've been able to solve some issues by using BIN and CUE files in place of the smaller PBP files that I think most people want to use. Basically, I'm going game by game and if it doesn't work with a PBP, I go for the BIN/CUE instead and so far I'm up to about 30 games all working great one way or another. I plan to get to around 80 or so games I think, whatever I can get on a 64GB stick. I have one of those super small ones that barely sticks out from the port at all, so I'm happy with that.
I DO want to figure out how to play 2-Player with this setup, but I haven't looked into it at all. I understand you may be able to use a hub or something but honestly I'm focusing on one thing at a time right now and for the moment, its just getting all the games I want on there. So far so great.