Damn this is a good pick.John Lennon - Mother
John Lennon was a piece of shit human being and I generally can't stand 70% of his solo work. But the first song on his first solo album makes me feel like the Beatles break-up was worth it. This is the kind of song you couldn't get on a Beatles album and it's positively heart breaking.
I much prefer the Otis Redding version.
Not many vocalists can give me legitimate goosebumps when they sing. Beautiful.