I haven't seen the episode yet, so I won't comment on the social commentary of the episode just yet.
I'll be very disappointed if the episode undermines the gravity of decision required to transition, and I'll be furious if the episode perpetuates fears of of men using transgenderism as a strategic vehicle for taking advantage of others in society.
Social commentary should require a situation in society to commentate on.
Hopefully, the situation in this case is "society's unfounded fears towards transgenderism" and not the process of transitioning itself.
I don't believe there has ever been even one case of a man strategically transitioning for nefarious purposes. The process is incredibly long and arduous. Nobody would ever go through it flippantly.
I will watch the episode hoping to find a subtle, satisfying conclusion at the end that is able to "invite" the uneducated viewer to re-think the transitioning process.
Over the years, South Park has consistently presented two opposing points of view to invite the viewer to make up their own mind, rather than argue and tell viewers what they should think. I believe this method is more effective at changing minds than any other method on earth (humour, talking on an equal level to the opposite side, and then demonstrating how ridiculous it is through analogy/story without judgment).
I'm hopeful they aim to change the mind of the lesser-educated by roping them in with a relatable smile, showing them how ridiculous their stance is, and then stepping back to let them arrive at their own, more empathetic conclusion about the topic of transitioning.
I'm optimistic that will be the case with this episode, but I will comment again after watching.