It's not an antibiotic, it's an anti-malarial. It also has immunosuppressive effects which is why it's used as a treatment for RA and SLE.
Yes.
-
Behold your winners! The ResetEra Games of the Year Awards 2020 results are finally live!
Trump: Hydroxychloroquine approved by the FDA for prescription to treat COVID-19 (UP: FDA says it is NOT approved, but currently in testing)
- Thread starter Gowans
- Start date
It really is something when Michael Patcher has a better track record.
Yep, except the drug is not mass produced due to low demand. It is unlikely that your local pharmacy has any in stock right now.
The OP states:
" A drug developed over half a century ago to treat malaria is showing signs that it may also help cure COVID-19 — especially when combined with an antibiotic, a promising new study reveals. "
Implying that the antibiotic is somehow improving the efficacy of the antimalrial. Clearly someone with viral pneumonia can be treated with antibiotics to help reduce co-infections, but the antibiotic has no effect on the efficacy of the antimalarial right?
Because, like, how the fuck would that work?
I asked my sister if she had ever taken hydroxychloroquine since she has rheumatoid arthritis, and she said she had. It turns out she's allergic to it, so hopefully other drugs will be as or more effective.
The FDA approved for covid-19 treatment part was wrong, BUT the French and Chinese studies are really encouraging. And generally we know the side effects.
Not sure re: the how, but those were the results. All six patients who had the combo were no longer contagious after 6 days, compared to 75% of those who only took the anti malarial drug, and ~10% of those who had nothing. The sample size is small, but still promising!
Idk I worked in a pharmacy for a long time and it was always in stock and there’s multiple generics. Wasn’t a fast mover in the auto counters but not really rarely prescribed. Still need a Doctor to write a script so can’t really have a run though I’ll guns you the cipro/anthrax deal back in the day.
If you are trying to say that malaria treatment doesn't sell like Aspirin, than I don't believe you
They'll just ignore that part like everything else.
No one except Emperor Trump could possibly come up with a cure.
Just so you know, Didier Raoult, the epidemiologist who touted choloquine as effective against the virus, is *extremely* criticized by French doctors. He did some good work in the past but the way he conducts the studies is far from ideal and his declarations about the efficiency of chloroquine are unethical at best, dangerous at worst.
I hope chloroquine works, but if people just start taking it like aspirin, we're in for quite a shock.
I hope chloroquine works, but if people just start taking it like aspirin, we're in for quite a shock.
I didn't see that part. Interesting that they combined it with azithromycin. Looking into it, azithromycin can apparently be used with atovaquone to treat babesiosis (another malaria-like parasitic infection). So it may have some synergistic effect.
It wouldn't be for bacterial co-infections since a lot of these people don't have pneumonia in the first place. And azithromycin wouldn't be what is used for bacterial pneumonia co-infections anyway, since those are often caused by staph aureus which it doesn't treat.
Azythromycin has anti-inflamatory effects not associated to the antibiotic effect itself. So that could be the logic behind it.
I mean everything.
“George W us the stupidest president ever!”
“This pop artist is the most egotistical narcissist ever!”
“Martin Shkreli is the most out of touch sociopath in history!”
“Nixon would put his political survival in front of a dying child while everyone watched!”
“There is no low that some CEO wouldn’t stoop to even if it destroyed the country “
“I wouldn’t be surprised if that famous dude had actually had people killed “
“that guy is the worst businessman of all time! A broken clock would make better decisions “
“I think that politician is a a traitor to his country “
“He’s probably a serial rapist “
“I bet he paid someone to do his entire degree in college and just screwed around there’s no way he could even graduate high school! “
“How can you tell when he’s lying? His lips move!”
All of these hot takes are typically easily disproven hyperbole — yet all of them are potentially factual statements about Donald Trump. Zero hyperbole. They’re all credible.
That's why there are multiple simultaneous tests taking place. I also don't see a world in which you could buy it like aspirin. For the sake of order, I imagine they would prescribe it with a positive diagnosis of COVID-19.
At this point I dont know why journalists have any interest in talking to Trump. Just bypass him and call other people. To be fair, despite his "Media are enemy of the people" shit, it would hurt is ego if he faced an empty press conference and the journalists published articles saying "There's no point any more, the man's an idiot"
Doubt it. That "anti-inflammatory" effect is thought of in the context of COPD exacerbations and airway inflammation/mucus production. And it's just a convenient "bonus" of the drug. The main use is still antibacterial. It doesn't replace steroids in treating the above.
Last edited:
Probably by killing some healthy cells that are targeted by the virus.
I doubt the synergy between the two because hydroxychloroquine is n-dealkylated by CYP3A4, which azithromycin doesn't really seem to use as a pathway to metabolize - if I remember my pharmacology correctly. Something like clarithromycin or erythromycin might be more synergistic pharmacodynamically. Also, I thought azithromycin was still very popular for use with community acquired pneumonia (CAP) or am I remembering my guidelines wrong?
I just read this. My eyes got really big.
I know he didn't say that....he couldn't have.
We have President Camacho during this pandemic. Great.
It's definitely being used, it's just not FDA approved yet. It's off-label at the moment.
Caveat: we are still at the throw the kitchen sink phase for the very sick/vented patients.
Caveat: we are still at the throw the kitchen sink phase for the very sick/vented patients.
Yes it's used for CAP, often with other antibiotics.
The macrolides are kind of weird antibiotics since they also treat a lot of infections from atypical organisms (mycobacteria, chlamydia, mycoplasma, etc.). That's why I looked into it a bit more and lo and behold it's used off label as part of the treatment for babesiosis. So there may be something to it when combined with hydroxychloroquine.
Azithromycin has pulmonary anti-inflammatory properties and is commonly used in patients with COPD that present with exacerbations. That is why it is being used in these patients.
www.sciencedirect.com
www.ncbi.nlm.nih.gov
Like I said earlier, it's literally throw the kitchen sink, anything that can theoretically help phase right now. The studies are too small at the moment to know if these things actually work, but we will know more as time progresses.
Anti-inflammatory mechanism of action of azithromycin in LPS-stimulated J774A.1 cells
Azithromycin is a macrolide antibiotic with well-described anti-inflammatory properties which can be attributed, at least partially, to its action on …
www.sciencedirect.com
Anti-inflammatory effects of macrolides--an underappreciated benefit in the treatment of community-acquired respiratory tract infections and chronic inflammatory pulmonary conditions? - PubMed
(1) Research into macrolide immunomodulation for chronic pulmonary disorders demonstrates consistent positive effects, although of types other than seen with diffuse panbronchiolitis. These effects, together with their inhibitory activity on biofilms, have the potential to make them a useful...
www.ncbi.nlm.nih.gov
Like I said earlier, it's literally throw the kitchen sink, anything that can theoretically help phase right now. The studies are too small at the moment to know if these things actually work, but we will know more as time progresses.
In this case it’s not that it doesn’t exist. It’s certainly promising. It’s just not FDA approved for Covid-19
Right, but he said that the breakthrough is available now. It's beyond misleading.
Fucker only cares about the stock market.
This is very real and used on trials in france with great results when used along with azithromycin . It's just that the sample is still very small
25 users, only 6 with hydroxychloroquine +azithromycin and 16 control group.
Good thing is that the control group was much younger than the other group, and the virus load after 6 days was much lower in the treated patients (and actually 0 in the 6 patients using both!. 100%).
This obviously needs to be fast-tracked to understand if this is simply a positive random trend or if it actually works.
The peer-reviewd paper about the trials
the draft paper that recommended initial trials
An Effective Treatment for Coronavirus (COVID-19)_
docs.google.com
Last edited:
there have additionally been multiple clinical trials in China that are showing very encouraging results
it's not a magic bullet and he jumped the gun on announcing it, but there are multiple promising candidates for anti-viral treatments that have already had their safety profiles established
so let's have hope!
it's not a magic bullet and he jumped the gun on announcing it, but there are multiple promising candidates for anti-viral treatments that have already had their safety profiles established
so let's have hope!
Thank youThe peer-reviewd paper about the trials
Google Docs - create and edit documents online, for free.
Create a new document and edit with others at the same time -- from your computer, phone or tablet. Get stuff done with or without an internet connection. Use Docs to edit Word files. Free from Google.docs.google.com
the draft paper that recommended initial trials
An Effective Treatment for Coronavirus (COVID-19)_
Could give a false sense of security, hope and a waste of time/resources?
After three years, you would think that people would learn that every word that comes out of Trump's mouth is a lie by now.