this was a common (now ineffective) anti-malarial drug. The risks are very well known (and they exist) that's why it's such a promising solution short-term.
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Trump: Hydroxychloroquine approved by the FDA for prescription to treat COVID-19 (UP: FDA says it is NOT approved, but currently in testing)
- Thread starter Gowans
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No. The drug doesn't have serious side effects and millions of people with Lupus already use it regularly. It's been around for a very long time.
Who is "we"? It won't be approved until it is shown to be effective. This isn't a medicine you just pick off the counter.
Btw, the initial study also mentions it can potentially be prescribed as prevention.
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So if it works it means even asymptomatic people can have this out of their system within a matter of days?
I mean, from what I hear it's dirt cheap, there is a ton of it already on shelves and lots of people are already getting their hands on it to self medicate. You don't have to be Lebron James to get it, which is what makes this drug in particular so hopeful.
i updated the links on my original post
trials https://www.mediterranee-infection....2020/03/Hydroxychloroquine_final_DOI_IJAA.pdf
draft paper https://docs.google.com/document/d/...JAGbdfF67WuRJB3ZsidgpidB2eocFHAVjIL-7deJ7/pub
the trials paper was immediately peer-reviewd by a well known doctor (well, i dont know him lol) Didier Raoult
trials https://www.mediterranee-infection....2020/03/Hydroxychloroquine_final_DOI_IJAA.pdf
draft paper https://docs.google.com/document/d/...JAGbdfF67WuRJB3ZsidgpidB2eocFHAVjIL-7deJ7/pub
the trials paper was immediately peer-reviewd by a well known doctor (well, i dont know him lol) Didier Raoult
True. Going to correct my post.
Yes. And it means that even people without the disease could take it to prevent it to take it.
A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19
COVID-19 (coronavirus disease 2019) is a public health emergency of international concern. As of this time, there is no known effective pharmaceutical…
www.sciencedirect.com
overview of ongoing clinical trials for chloroquine use against covid-19 in China
How long does it take to produce pills like these?
Canada makes generics so maybe they can make these if they prove successful?
Canada makes generics so maybe they can make these if they prove successful?
I think the main idea is simply to heavily reduce the virus load, recovering patients much quicker and thus not crashing the health systems.
You are right, it's going to the prioritized. Check this out form the original paper.
Considering that it was already theorized to work on SARS patients, although only in 2004 when SARS was no longer around, a lot more hospitals should be trying this on the worst patients.
It is supposedely fairly easy to produce, it is just that nobody does because there are better products for malaria. There is a Dutch firm that makes it small scale for treatment of rheumatism that claims it can easily produce enough to foresee a large part of Europe. They just can't take the risk of making it and then nobody buying it.
You would prioritize health care workers, those who are critically ill, and then target senior populations first.
These are extraordinary times too, this is like a war, it's incumbent on the private sector to mobilize with the government, if this drug has efficacy, then it must be the no.1 priority of all nations to mass produce it ASAP.
If this works, then drug makers, all of them that are capable of producing this need to prioritize making it. At the order of the government if need be.
It's one of the most common drugs used to treat various rheumatologic disorders.
Because once it gets into the lungs it feeds off of bad bacteria and creates more complications causing the body’s immune system to go into overdrive. Fighting the bacteria is part of fighting off why people are dying.
Because by accident, I found a nice Dutch source for it, in Netherlands, a country of 16 million people and estimated 2 million people with one or other rheumatologic disorder, 300 people are using this thing.
These are all emergent therapies. I know some hospitals currently have it in their protocol to use hydroxychlorquine for Covid-19 positive patients. Normally I don’t blame the public for not understanding the difference between “FDA-approved” and experimental therapies that are being used that show promise, but he’s the president and should know better.
There are a lot more than 300 people using this. I would say about half of the SLE or RA patients I treat are on this. And that's a conservative estimate.
So what you're saying is that this potentially cheap and easy to produce Drug can work as a temporary immunity/prevention, and treatment that works on all stages of the Virus? Especially early stages? That sounds way too good to be true but good god I hope it is because leaning on this thing would be way better than shutting everything down for months on end.
Bayer (maker of Aspirin) donated a large amount of hydroxycholorquine to the US government for use against COVID19 ... I think that's what Trump is talking about.
They donated 3 million tablets.
wtvbam.com
They donated 3 million tablets.
Bayer donates three million malaria tablets to U.S. for potential use against coronavirus
(Reuters) - Bayer AG said on Thursday it has donated 3 million tablets of the malaria drug Resochin to the U.S. government for potential use to treat COVID-19. Resochin, made of chloroquine phosphate and an approved treatment for malaria, is being evaluated in China for its potential use against...
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Yes, that's what they are saying. It potentially can work like that.
The most promising result was obtained on 6 people (this is the issue, the sample is way too small) that when treated with this (hydroxychloroquine) plus azithromycin, all 6 got cured and in 6 days.
Hmm.
www.reuters.com
Potential coronavirus treatment touted by Trump already in shortage, pharmacists say
An old malaria treatment that has been tried with some success against the new coronavirus and was touted by U.S. President Donald Trump at a news briefing earlier on Thursday is in short supply as demand surges amid the fast-spreading outbreak.
www.reuters.com
All of this was in motion before dumbass went and called it "FDA approved" when it wasn't, but it's not going to help things.
Its most likely that there's a shortage because of their ordering based on speculation(it's been rumored for a few days now). I would imagine production hasn't ramped up because it would be too premature.Hmm.
Potential coronavirus treatment touted by Trump already in shortage, pharmacists say
An old malaria treatment that has been tried with some success against the new coronavirus and was touted by U.S. President Donald Trump at a news briefing earlier on Thursday is in short supply as demand surges amid the fast-spreading outbreak.
All of this was in motion before dumbass went and called it "FDA approved" when it wasn't, but it's not going to help things.
At this point are there reasons to avoid actually ramping up production in case it works ? If it works, it could save many lives, and every day would count.
Would be amazing if this really ends up working, an already existing known drug that can potentially prevent and treat this would be huge in battling this
Someone in the administration needs to scarifice themselves and stand up to Trump (not Fauci since he seems actually competent,) and tell this cheeseball to stick to the fucking script. Everytime he goes off it, he reveals profound ignorance, causes confusion, and puts the country at more risk.
Small sample size indeed, but that is at least somewhat encouraging. I will remain cautiously optimistic for now.
The other interesting thing about that is actually 5/6 patients were cleared completely by day 3.
The sixth person took an extra 3 days to be clear at day 6.
I am so glad I stocked up on my meds.
I’m so, SO glad I already filled my script for the next couple months.
It is though?
Most studies I have read seem to point out that the treatment is very effective if taken early. I'd say what matters now is to define what that "early" window is.
Daniel Dale @ddale8The FDA has issued a statement clarifying the chloroquine situation. Trump wrongly said the anti-malaria drug was approved for coronavirus. The FDA statement says there is no approved coronavirus treatment. 1/
The FDA says:
- It's working with govt/academic entities already studying chloroquine for coronavirus
- It will continue to grant emergency compassionate use requests for another drug Trump mentioned, remdesivir, "but controlled clinical trials are needed" to test safety 2/
- Hahn:: If chloroquine works for coronavirus, demand will increase; they'll "take all steps" to keep it available to "patients who take it to treat severe and life-threatening illnesses such as lupus.” They want makers to ramp up production to mitigate any supply pressures 3/
Hahn: This situation is urgent, but “we also must ensure these products are effective; otherwise we risk treating patients with a product that might not work when they could have pursued other, more appropriate, treatments." 4/4
The FDA says:
- It's working with govt/academic entities already studying chloroquine for coronavirus
- It will continue to grant emergency compassionate use requests for another drug Trump mentioned, remdesivir, "but controlled clinical trials are needed" to test safety 2/
- Hahn:: If chloroquine works for coronavirus, demand will increase; they'll "take all steps" to keep it available to "patients who take it to treat severe and life-threatening illnesses such as lupus.” They want makers to ramp up production to mitigate any supply pressures 3/
Hahn: This situation is urgent, but “we also must ensure these products are effective; otherwise we risk treating patients with a product that might not work when they could have pursued other, more appropriate, treatments." 4/4
4:37 PM - Mar 19, 2020
Needs more testing before anyone can make definitive statements regarding efficacy and before FDA approves it for use.
Sure, that does not mean doctors cannot use it as a first line of defense, as with Kaletra, remdesivir and favipiravir.
Comforting, I suppose. I Am Legend accidentally creating feral zombie vampires after releasing the cure for cancer always stuck out in the back of my mind
That's not how it works. I can't just "give" stuff to patients that are not approved for use or at the very least considered standard of care. Hydroxychloroquine right now is neither. It's still in the testing phase and can only be given to patients who are part of those trials. The drug may amount to something. It may also amount to nothing.
You are painting a grim picture over a medicine that's been safe to use for over 50 years. And as far as I am aware, doctors are approved to apply therapeutics by discretion, like intubation and sedation or drugs with confirmed and logical potential.
"Off-label" doesn't mean "prescribe whatever the hell you feel like". Evidence based medicine is standard of care. There are still guidelines on what can be prescribed off-label.
Safety is not the issue (although even that would have to be studied in the setting of an active or recovered COVID19 infection). Efficacy has to be demonstrated. And right now it's just too soon to claim efficacy.
That's what discretion looks like. It's not "Oh, look 6 people in China got better let's start throwing Plaquenil at everyone!". It needs to be studied to determine if it actually works or not.
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The French study showed enough promise that Bayer gave the US government 3 million hydroxycholroquine pills.
Don't think the FDA is up to this task of handling this pandemic, they are way too slow. They have rules and regulations, but those don't take into account a situation like this. Probably countries like France have to take the lead.
It was more than 6 people that got better until hydroxychlorquine btw in the French study. The 6 person group just showed better results with a second drug added.
That's fine. Still not enough data right now. If more and more data like that starts to come out and the evidence looks solid, then I'm sure the medicine will start to be used irrespective of FDA approval.
If I had a loved one who was ill with COVID19, I would ask the doctor to prescribe the same drugs in the French study off-label and/or remdesivir which is being used on compassionate grounds.
Not gonna sit around waiting for the FDA to take several months or however they normally work just to conduct a first wave study.
There's like 7 or 8 people now on this board that take plaquinel/hydroxchlorquine regularly at least it seems. Probably more, those are just the people that I've seen mention it.