Each character in South Park has their own personality, and you can generally tell ahead of time how people will react to many situations.
Kyle will always be the most open to differences, as will Stan. Cartman will often be bigoted toward them (unless he's using them for his personal gain, in which case he'll defend them to the death), Kenny will usually be cool with just about anything, Butters will be confused and not understand, Cartman's mom won't care, Kyle's parents are generally really conservative and will be upset, Butters' parents are disciplinarians and will punish for literally anything, and Stan's parents are generally pretty open.
My point being you've got to know the world you're stepping into. If you're oblivious to South Park, I don't think the game or the writers should necessarily worry about how you will interpret things.
Kyle will always be the most open to differences, as will Stan. Cartman will often be bigoted toward them (unless he's using them for his personal gain, in which case he'll defend them to the death), Kenny will usually be cool with just about anything, Butters will be confused and not understand, Cartman's mom won't care, Kyle's parents are generally really conservative and will be upset, Butters' parents are disciplinarians and will punish for literally anything, and Stan's parents are generally pretty open.
My point being you've got to know the world you're stepping into. If you're oblivious to South Park, I don't think the game or the writers should necessarily worry about how you will interpret things.