Loved metal gear solid. Beat it when I was in high school. Saved money, traveled in Europe, went to college and didn't own a new console til ps3. Totally skipped ps2. I actually own the mgs collection for ps3 but I've never tried it. I kept putting it off and then just never got around to them.
Same with mass Andromeda 3. Bought the collection for ps3. Played the first, actually wrote about the second for a class in grad school, and then never played the third. Not because of the controversy; I just took a break and meant to get to it and never did.
Not the most exciting answers but mgs and me2 are some of the most impactful and fun times I've had gaming but I didn't continue the adventure. Uncharted on the other hand I did finish and I really loved the ending to UC4. I thought it was such a special and touching scene.