Hard choice as it's been a while since I last watched the Wire. Like seven years while.
I remember Season 1 blew my mind back then. It opened my eyes to the inner workings of police and city politics, but also to the life of gangs and people who get caught in between. Season 2 was a slight dissapointment since it moved away from that and featured more of criminal aspects of Baltimore port terminal. Then again I'm Polish so it will always gets props from me for showing the life of Polish-Americans. I grew to respect Pryzbylewski, symphatize with Sobotka and loathe Valczek.
Season 3 and 4 I barely remember. Was it the Hamsterdam and Marlo stuff? Never watched the fifth season.
I sincerely hope Baltimore is nothing like it was shown in that show now though. Because it seemed like a genuinely awful place.