I mean, it's streak that's gonna have to be broken if/when a Fantastic 4 movie comes out, but the Fox X-Men have pretty much been the Charles/Magneto/Jean/Wolverine (and to a lesser extent Cyclops) show for the whole run, with different important supporting characters depending on the era (Rogue, Storm, Iceman pre-DOFP and Mystique/Beast/Quicksilver post DOFP). They could do a movie centering other characters instead, like Kitty Pride as a simple example.
I'm not saying Charles Xavier won't exist in the world, just that I don't think he'll be a character that's central to the story like he has been up to this point.