The Witness seemed pretty self-aware, at least as I understood it, about the line between trying to find patterns to understand the world and get closer to Truth, and getting so consumed by a search for some underlying Big Answer that you lose perspective completely. I felt like the FMV that serves as one of the game's endings was one way of acknowledging that (the "player character" emerging from the virtual world of The Witness and staggering around looking for the game's patterns, which outside of that world are totally pointless). Similarly,
The Secret of Psalm 46 GDC lecture that's in the game (the environmental puzzle that requires you to listen to the whole thing is an all-time great stupid gaming moment, and it ties into this very idea) is largely about how people get carried away by the hunt for Easter eggs and hidden puzzles, whether that's the truth of Shakespeare's identity or codes hidden in the Bible or conspiracy theories.
Drawing lines or creating patterns can be very fun, but it's not necessarily good for you all the time.