I thought the movie was quite solid, and probably the best human characterization that's ever been in a Spiderman movie. I loved the human touches with the Hispanic mom, the way the children acted at the different schools, the emotions, etc. The world and characters felt realistic, despite a world of crazy happenings. I felt like I had eyestrain afterwards and the opening credits were seizure-inducing, but thankfully most of the movie wasn't like that. It was probably the most comic-book-looking movie I've ever seen.
One of the few weaknesses to me was Miles' father and uncle. Someone already mentioned the father not even wondering why his brother was in a weird supervillain power suit. The other weird thing to me was when Miles finds out it's his uncle, he doesn't even ask "why", which I would think would be a human reaction. And the uncle is just like "yeah I let you down my bad" instead of even offering any motivation like "despite my desire to be an independent graffiti rebel, I sold out to randomly murder people while wearing a supervillain power suit because I just like money that much" or something. :P Like, there has to be a reason he goes full villain despite apparently being a decent person in most other aspects (pick-up artist skeez aside).
I wasn't too surprised about something happening with the uncle since it was sort of hinted at, but for some reason I was totally not expecting Doc Ock. I found out the scientist was working for Kingpin and was like "ah she's evil or doesn't care about evil as long as she can science" and then BAM, power suit.
Random reference thing, I loved the newspaper and other Spiderman references, and most of the ones I noticed were from the Tobey Maguire series. Were there any from Amazing Spiderman or the new Avengers version?
Also my random favorite thing was Nicholas Cage and his Spiderman Noir touches. "I'm taking this cube thing. I don't understand it...but I will."