Look dude if space exploration can give the Fantastic Four super powers, it can give balding men hair.
Currently, the predominant hypothesis explains androgenetic alopecia (AGA) as a process reliant upon affected follicles being individually programmed to accumulate dihydrotestosterone (DHT), which then causes progressive follicular miniaturisation. The goal of this paper is to suggest that such miniaturisation may result from an exaggeration of the bone remodelling process causing a reduction in blood supply to the capillary network within the affected region. The bones of the human skull continue to grow during adulthood and observations made of those with AGA suggest that such growth may be responsible for the development of this condition. Studies of human cranial anatomy indicate that frontal and parietal bone growth can account for the development of the male pattern baldness (MPB) profile and the variations that can occur in the rate and location of hair loss. Steroid hormones such as DHT promote facial and body hair growth. Logically, this suggests that DHT should stimulate hair growth within the MPB region and not hair loss. However, DHT also has an anabolic effect on bone formation, and it is hypothesised that this stimulation of bone growth will overwhelm the hair growth promoting effects of DHT. Androgen receptor sites, 5-alpha-reductase (5alpha-R) and DHT have all been associated with AGA, but they also exist within numerous types of bone cells. DHT will stimulate the proliferation of osteoblast cells and the formation of new bone. Verification of this hypothesis would imply that DHT is primarily involved with AGA through its stimulation of the skull expansion process rather than through interaction with individual follicles. Also, increased androgen receptor gene expression, 5alpha-R activity and subsequent production of DHT within the MPB region of balding individuals, may simply represent the body's attempt to compensate for the skull expansion expression of hair follicle miniaturisation. Furthermore, it suggests that MPB region follicles are not individually programmed for hair loss. A redirection of genetic research towards the identification of those genes responsible for skull shape and development would be appropriate, and may reveal the genetic connection to AGA including its paternal link.
The follicle might be gone, but we could always make a new one. We can lab-grow meat! Let's get that ball rolling. Not there yet, but maybe someday.Well, we know what causes MPB and how to prevent it, the issue is that once the follicle is dead, its dead. There's no bringing it back. But Finasteride and Duasteride already do a very good job of suppressing DHT, the issue is most people aren't proactive about hair loss and don't start a preventative routine until it's too late.
Yeah, rich transplants look relatively normal.Isn't it already possible, just ridiculously expensive? Hair transplants; Elon Musk, Tobias FĂĽnke, etc
Finasteride for hair loss is extremely expensive, which is probably part of the reason why no progress has been made in a long time. Pharma knows they can get dudes to pay a shitload of money over and over and over again, whereas a one-time treatment is a one-time payment.
The irony? Higher doses of finasteride are significantly less expensive.
STEM ERA,
It's 2018. How is there no cure for hair loss?
*I'm actually quite curious.
You can get a month's supply of 5 mg (which is a super higher dose for treating mpb) Finasteride for like $30
https://www.inhousepharmacy.vu/p-2081-prosteride-finasteride-5mg.aspx
Cut the pills in half and it comes out to like $15 a month.
Finasteride for hair loss is extremely expensive, which is probably part of the reason why no progress has been made in a long time. Pharma knows they can get dudes to pay a shitload of money over and over and over again, whereas a one-time treatment is a one-time payment.
The irony? Higher doses of finasteride are significantly less expensive.
Success of projects in the pharmaceutical or biotech industry is measured in the 10-20% range (and that's optimistic).Imo, I honestly think rocket science is easier than curing baldness
I get mine from Walmart for around 45 bucks. So basically around 520 a year to avoid going bald.
CRISPR has really great promise, but it is still just a tool. A much more precise tool than gene editing tools that have been around for many years (gene editing existed before CRISPR), but still a tool nonetheless.
STEM ERA,
It's 2018. How is there no cure for hair loss?
*I'm actually quite curious.
That's kind of a risky decision considering some experience permanent side effects.Well, we know what causes MPB and how to prevent it, the issue is that once the follicle is dead, its dead. There's no bringing it back. But Finasteride and Duasteride already do a very good job of suppressing DHT, the issue is most people aren't proactive about hair loss and don't start a preventative routine until it's too late. If the men in either side of your family have a history of MPB, you should be staring Fin at age 18 regardless if you've yet to experience any recession or not.
We haven't solved allowing everyone to grow a kickass beard yet either.Well, the moon can't shave baldness away, get ripped and grow a kickass beard.
Well, the moon can't shave baldness away, get ripped and grow a kickass beard.