Lets begin.
Hasbro, a company that in the past year tried to kill the TTRPG industry because they weren't making enough money, send the fucking Pinkertons after fans of their products and fired 1100 workers last year, made $90m in profit from the game. OK so it's harsh to lay all that at Larians feet but yeah, it sure is distasteful.
5th Edition D&D is a godawful system that's barely acceptable at doing the thing it claims to be doing, namely killing things and taking their stuff. It's not good for building a variety of crunchy characters. It's not good for tactical combat. It's not good for character stories. There's far better systems for all of those things but instead we have to deal with the blandest system imaginable.
You can see how this negatively impacts the game in a variety of ways. Inspiration points are there to counter the absolutist nature of D20 rolls, where if you fail you just fail rather than get to progress the story in a meaningful way. So Larian throw inspiration points at you to work around this basic failure in the D&D system. There's better ways to do this, though historically it's been lacking in CRPGs, with only really Disco Elysium showing a better way of doing things. Disco Elysium not using a D20 system isn't a coincidence.
Combat boils down to burst damage and preventing the enemy taking turns. You go first and action surge for massive damage (and everyone can action surge cause D&D 5th Edition character creation is garbage) or don't and everything descends into a slog, especially as Larian's only response to combat late game is to just throw huge numbers of enemies at you, or give the boss characters legendary actions to break the game (again, cause 5th Edition D&D is awful).
Or you just take Tavern Brawler and trivially break 5th Edition's bounded accuracy and break the game in your favour. Yay.
Larian's attempt at party/inventory management is laughably bad. The game spent three years in early access and they never bothered to meet the standards met in BG1? I mean that's inexcusable.
Minthara completely spoiled the major plot points for several other characters in my first conversation with her as a party member. Again, for a game that spent three years in early access, that's an inexcusable bug, and probably the worst I've seen in a CRPG. And I play Owlcat CRPGs. And from what I've seen she's still insanely bugged.
Why is every character a super model? Why does Gale have a six pack? Why is Karlach's face entirely untouched by the massive scars across the rest of her body. We know why, cause people might not be endlessly attracted to the characters if they had any flaws.
On that note, I've seen straight up hentai games that are less horny than this game. I'm no prude, but bloody hell the level of horny this game puts me right off. Minthara's sex scene was straight up pornographic.
The character writing honestly boils down to 'pick your trauma and fix them'. It's very repeatedly one note for the characters and gets kinda dull. The performances are great, no complaints there.
The main quest is similarly kinda average. It starts off with a promising 'save yourself from not Johnny Silverhand' angle but devolves into the usual dull 'save the world, no wait the whole cosmos' angle that infests any number of CRPGs. They'd have done much better to stick to the low stakes.
Especially as, because it's 5th Edition D&D, there's no chance they can balance or create interesting encounters for high level play. The game straight up breaks at those levels.
As for choices, the game promises that you have all these choices but really it boils down to three at the end. Destroy the Nether Brain, enslave the Nether Brain or choose the above as the Durge. Throne of Bhaal 20 years ago had the same level of choice in its end game.
It's gaming's hottest 6/10 and maybe it'll get more players into CRPGs, but I've heard that from years of 5th Edition D&D being the only thing played in TTRPG circles so I don't have much hope of that.