Drunk? Sometimes a good idea, but usually not. A mild buzz can give me a boost of confidence, which is helpful, but that's about it. Sloppy hands lead to sloppy controls. Basically, I can beat most Souls bosses after a few drinks, due to not overthinking my moves, but getting through an area full of hordes and traps is usually a mess.
High? Depends on the game. I love playing walking simulator type games when I'm zoinked, but it's immersion overload and I tend overlook fine details. FPS / shooter games are usually easier after smoking a bit, helps your focus/reflexes. 3rd person action/adventure games can sometimes be extremely puzzling when you're total baked potato, like finding a path or key item or something of that nature. Think Witcher 3 quests.