I mean, honestly, I think you can make jokes involving whatever, but in addition to being offensively punching down and attacking minorities, a lot of what Family Guy does is also shitty jokes that are nothing BUT that. Like, in addition to being really crappy and hurtful to a vulnerable group of people, jokes that hinge entirely on "ew, trans people are gross, right guys?" are pretty terrible jokes regardless, even ignoring how highly problematic they are. Stuff like that is just awful, awful "comedy" all around, and I don't think anyone should be lamenting it going away.