Yeah, it's kind of crazy that a show where one of the leads had a transexual parent could be considered homophobic or a problematic show in general. Sure, there are gay jokes about Chandler. There are fat jokes about Monica. There are jokes about how dumb/Italian Joey is. There are jokes about Ross being an archeologist. There are jokes about the dumb bullshit that Phoebe believes. There are jokes about Rachel having a nose job. Everyone is mocked gently in equal measure, it is a comedy.
You can critique the show for being representative of most 90s sitcoms with it's white cast of mostly aimless rich people but I think it's a stretch to call it a harmful show. It's simply a show that wouldn't be made the same way in 2019.
Someone in this thread actually said that it's still causing negative cultural impact in 2019 lol.