I'd be fine if I never played anything with vampires (or zombies) ever again, but I am very much here for the "open world in a small New England town" angle. Especially since I grew up in a small New England town. There's a lot of meat on that bone and tons of cool ideas I could see, depending on how they chose to go with the story and design.
Honestly, none of that really matters, because I'm going to be buying this regardless. I am very much at the "shut up and take my money" stage with Arkane.
I've actually been replaying Dishonored again the past couple weeks, just got to the Daud DLC. Still holds up great. I notice something I never did before in every single playthrough. The people at Arkane are just so, so talented and good at what they do.