Sweet jesus that was terrifying.
I don't think anyone here is bad but Luis is easily the hardest to use and requires wringing the most out of your RE4 knowledge. I find the trickiest part is initially kiting around the map to hit the time boosts while holding a combo, since you often have to do things like climb a ladder and headshot someone with the bolt action afterwards to stagger the combo reset while moving your slow ass around.
His mayhem is key to everything, even moving around the map since you can leave it behind you and keep on trucking, OR abuse the fuck out of the i-frames, deploying the tnt makes him immune and he takes no self damage from the explosion, so you can run at a chainsaw, drop it right at their feet then shoot the ground point blank. It's like bombing the spot Luis is on and he can do it multiple times per use, and gets it back quickly. It makes it the best thing to get people off you.
Otherwise, Leon is just solid as fuck. Strong weapons, strong mayhem.
Krauser and Hunk are completetly broken. Looking at the leaderboards, Krauser seems the best for score? It seems like melee kills give time so knife comboing everything is probbaly also getting you the most time and score. He is drowning in i-frames during it and even if you take hits rarely gets interrupted, has maxed out health on top of it and it's not like his kit is otherwise bad. Bow is great, mayhem is amazing, knife doesn't break. Enemy transforming on the ground? No reason to not stab them. Hunk has the instant kills but krauser basically does too, since you can always just flash -> shank with an unbreakable knife, albeit not on boss enemies.