I'm far from beating the game but just a summary of some tips I found in this thread (and some I discovered organically) that helped me get to Biome 3 where I'm currently rested:
1. Yes, you can heal at the spacecraft in the first biome. Ensure you're fully healed before picking up Silphium so that you can increase your max integrity.
2. Is the astronaut figurine available to buy? Don't hesitate to buy it as it's an extra life.
3. Don't underestimate the value of an old fashion large health vial. Buy it for the boss fight.
4. Buffs related to integrity (health) are valuable. Parasites that heal when low, artifacts that leeches life (super good)... this is obviously luck based on what you come across but I have seen many interesting variants.
5. Don't gamble on Malignant/harmful items unless: A) You already have an item for cleaning malfunctions. B) It's a parasite where the trade-off is clearly stated. There are also some items later like Resin that is 50/50 chance for increased max health or damage. I chance them.
6. Weapon options can be persistently & permanently upgraded. If you see a weapon with an ability that has 0%~99% (and seems promising) then consider picking it up. Using the weapon will build towards unlocking the ability for all future cycles.
7. Don't user Ether to clean stuff... save it for the resurrection/cloning machines. When you know you are close to a boss (or you are fearing to lose a lot of progress) then these will be very handy. Note: If you leave the biome you will have to pay for a new entry.
1. Yes, you can heal at the spacecraft in the first biome. Ensure you're fully healed before picking up Silphium so that you can increase your max integrity.
2. Is the astronaut figurine available to buy? Don't hesitate to buy it as it's an extra life.
3. Don't underestimate the value of an old fashion large health vial. Buy it for the boss fight.
4. Buffs related to integrity (health) are valuable. Parasites that heal when low, artifacts that leeches life (super good)... this is obviously luck based on what you come across but I have seen many interesting variants.
5. Don't gamble on Malignant/harmful items unless: A) You already have an item for cleaning malfunctions. B) It's a parasite where the trade-off is clearly stated. There are also some items later like Resin that is 50/50 chance for increased max health or damage. I chance them.
6. Weapon options can be persistently & permanently upgraded. If you see a weapon with an ability that has 0%~99% (and seems promising) then consider picking it up. Using the weapon will build towards unlocking the ability for all future cycles.
7. Don't user Ether to clean stuff... save it for the resurrection/cloning machines. When you know you are close to a boss (or you are fearing to lose a lot of progress) then these will be very handy. Note: If you leave the biome you will have to pay for a new entry.