I ended up liking the show quite a bit. I think it does a really clever job of weaving stuff from the games in without relying on them as critical plot elements in most cases. To me, it's far better to have a show that uses references in clever ways rather than strictly adheres to the canon of the games. The reality is that there is no canon for Resident Evil and accepting that makes it an infinitely better series. Getting caught up in the details, that ultimately don't matter at all, anyway, just bogs it down.
The story gets to use the existing characters and world and fit them to a narrative that is more appropriate for TV than the narratives of the games would be, especially since the games barely have narratives in the first place. Is it a great show? No, not really. But I kind of think if it was a truly great show, it would cease being RE, anyway. Being weird, camp, confusing, and contradictory is well in the spirit of the games, and so I think it was pretty successful. Hopefully it gets a second season as there is so much to potentially explore.