Here are some tips for those that are returning to the game and looking to go deeper in the Gungeon:
- Keep unlocking stuff. The more you buy items, the more you risk encountering good stuff on your runs, which will definitely give you a much better fighting chance.
- When there are lots of bullets flying around, don't rely too much on dodge rolls. It's too easy to end up your roll on an enemy bullet. Try to simply walk around the bullets instead. If you absolutely must do a dodge roll in such a situation, blanking mid-roll is often a life saver.
- Especially when the action gets crazy, try to keep your eyes on your character instead of on the enemy you're shooting. It makes it much easier to walk around bullets without taking damage.
- The rarity order of regular chests are (from common to very rare): brown, blue, green, red, and black. Don't bother wasting keys on brown chests. Keep your hard earned keys for blue chests and above. Some say to also avoid the blue ones, but I very often find really good items in them, so now I try to open the blue ones when I have spare keys.
- Try to explore the whole floor before opening chests. You'll not like it if you waste your only key left on a blue chest to later find out there was a black chest on the same floor...
- Always destroy the chests you don't open. But do it at a distance because some will explode. You'll often only get a piece of junk, but sometime you might get a nice surprise...
- There is usually at least one secret room per floor. Those hidden rooms are opened with a blank (or a big explosion). Telltale signs of such a room are cracks on a wall that appear if the bullet of one of your guns hits its entrance. Unfortunately, starter guns will never reveal a hidden room.
- If you still have spare blanks after a boss, try to discover a secret room. Don't worry, you'll automatically get two new blanks on the next floor. The most common places to find secret rooms are: chest rooms, special rooms with an NPC in it, and the elevator room after the boss. So if you have no clue where the hidden room is (no cracks on any walls, and you don't want to randomly waste precious ammo), take a guess and use your unused blanks in those kinds of rooms before moving on. You might get lucky.
This is what I can quickly think of. I'll try to find other tips that could be helpful.
