I agree that the overall message in the game would challenge vergils perception rather than reinforce it, but just the choice alone to equate feelings and sensitivity with females is tiring in itself. And to top it off? She would end up "sacrificing" herself "for a man". Just nah to all of it.
And I suppose there is also the point V is weak himself and the demons do the fighting for him. Playing into another trope if he was a woman.
Maybe the story would have to be rewritten more for female V. Or just make Trish or Lady playable instead of what they did with them.
I am just disappointed a female playable character was in the cards and they decided against it.