Bethesda refer to Wastelanders as year two and so people start to put down roots but I don't see them removing the year one main quest for new players.
However becoming a new player now already seems daunting to me with the sheer amount of catch up needed.
Strangely enough, I'm (possibly?) coming to the game at this latter point and am excited about all of the content that I need to do to catch up. At launch, I was afraid the game would be kinda barebones so this suits me just fine :)