I think its a step too far to immunize the female NPC's in the game. Cause that is a rabbit hole of asking why anything is able to be attacked in a game where freedom is the biggest draw. The issue should be those who choose to glorify said actions being held to account
I'm not saying make all female NPCs immune to violence. What I am saying is that if an NPC male/female not tied to the central story plot identifies as a real world civil rights ideology or movement it should be best not to allow them to get killed.
EDIT: This goes for all games that push for real life realism. Not just R* games